Authors: Hafiz Muhammad Ameer and Muhammad Iqbal

JSA-Vol. 3 (2024),

Abstract: Nonsteroidal anti-inflammatory drugs are a well-established drug class that is widely known to cause significant pain relief and inflammatory diminishment. In the research under consideration, several important descriptors of molecular structures that relate to the NSAIDs were considered, especially concerning their Sombor indices. In this paper, I shall calculate the different ranges of NSAIDs by evaluating their structural features related to crucial physicochemical properties. Our employment of logarithmic regression is carried out through QSPR modeling frameworks with an intent of making powerful mathematical models that relate the Sombor indices to other pertinent attributes of NSAIDs in relation to pharmacodynamics and toxicological parameters, thus illuminating how molecular composition dictates its behavior toward biological processes and their global drug profiles. Utilizing logarithmic regression, we are able to show an efficient approach in capturing nonlinear relationships between molecular structures and drug properties and further contribute to the progress of drug design and development.